Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migraine
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-lymphocyte-associated antigen-4.
Cancer immunotherapy relies on the ability of the immune system to target tumor-specific antigens to generate an immune response. This initial response requires both binding of the MHC/antigen peptide to T-cell receptor complex, along with a second costimulatory signal created by the binding of CD28 on the T cell, with B7 located on the antigen-presenting cell. Regulatory checkpoints, such as c...
متن کاملthe cytotoxic t lymphocyte antigen-4 +49a/g single nucleotide polymorphism association with visceral leishmaniasis
conclusions according to the results, the polymorphisms within the +49 position of ctla-4 can be associated with vl and may be considered as risk factors for the disease. results our results indicated that both ctla-4 +49a/g polymorphisms were significantly associated with vl. materials and methods in this cross-sectional study, 88 patients with clinical presentations of vl, who were seropositi...
متن کاملCytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases.
OBJECTIVE The cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is expressed on T lymphocytes, and inhibits the T-cell responses. In animal models, it has been shown that complete CTLA-4 deficiency was lethal due to massive infiltration of tissues by polyclonally proliferating lymphocytes. CTLA-4 A49G polymorphism, which has been suggested to reduce the inhibitory function of the CTLA-4 mole...
متن کاملCytotoxic T-lymphocyte Associated Antigen-4 (CTLA-4) Polymorphism, Cancer, and Autoimmune Diseases
Immune system dysfunction is one of the key features in onset and development of cancer and autoimmunity. Cytotoxic T-lymphocyte-antigen-4 (CTLA-4), as a leader immune checkpoint plays a crucial effects in the regulation of immune suppression and tolerance. In this review, role of CTLA-4 and its three important polymorphisms (SNP), CTLA-4 +49A/G, CTLA-4 CT60 A/G and CTLA-4 −318C/T in developmen...
متن کاملCytotoxic T lymphocyte antigen - 4 and immune checkpoint blockade
Introduction The immune system is an important defense against the development and progression of cancer (1). Historically, there has been a waxing and waning enthusiasm for immune therapies to treat cancer due to limited efficacy. Immunotherapies, such as IL-2 and adoptive transfer of autologous tumor-infiltrating lymphocytes, can induce durable tumor responses in a subset of patients, leading...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2005
ISSN: 1129-2369,1129-2377
DOI: 10.1007/s10194-005-0181-2